902691

Hydroxy-PEG5-t-butyl ester

• Sinonimo/i: tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• Formula empirica (notazione di Hill): C₁₇H₃₄O₈
• Numero CAS: 850090-09-4
• Peso molecolare: 366.45
• Numero MDL: MFCD20926402
• Codice UNSPSC: 51171641

Proprietà

• Saggio: ≥95%
• Stato: liquid
• Impiego in reazioni chimiche: reagent type: cross-linking reagent
• Indice di rifrazione: n/D 1.448
• Densità: 1.071
• Gruppo funzionale: ester; hydroxyl
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Altre note

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable