910015

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

• Sinonimo/i: Azido-PEG₅-CH₂CO₂H, Azido-PEG₅-acid, N₃-PEG₅-CH₂COOH
• Formula empirica (notazione di Hill): C₁₂H₂₃N₃O₇
• Numero CAS: 217180-81-9
• Peso molecolare: 321.33
• Numero MDL: MFCD31561141
• Codice UNSPSC: 12352106

Proprietà

• Saggio: ≥95%
• Stato: (Liquid or Semi-solid or Paste or Solid)
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: cross-linking reagent
• Gruppo funzionale: azide; carboxylic acid
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG₅-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Altre note

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable