902527

Amino-PEG5-t-butyl ester

≥95%

• Sinonimo/i: tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H₂N-PEG₅-CH₂CH₂COOtBu
• Formula empirica (notazione di Hill): C₁₇H₃₅NO₇
• Numero CAS: 1446282-18-3
• Peso molecolare: 365.46
• Numero MDL: MFCD25424125
• Codice UNSPSC: 51171641

Proprietà

• Saggio: ≥95%
• Forma fisica: liquid
• Impiego in reazioni chimiche: reagent type: cross-linking reagent
• Indice di rifrazione: n/D 1.4534
• Densità: 1.4690 g/mL
• Gruppo funzionale: amine; ester
• Temperatura di conservazione: −20°C
• Stringa SMILE: NCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): No data available
• Punto d’infiammabilità (°C): No data available