QBD10501

Azido-dPEG^®₄-NHS ester

• Sinonimo/i: 3-(Azidotetra(ethyleneoxy))propionic acid succinimidyl ester, NHS-Peg4-Azide, Polyethylene glycol
• Formula empirica (notazione di Hill): C₁₅H₂₄N₄O₈
• Numero CAS: 944251-24-5
• Peso molecolare: 388.37
• Numero MDL: MFCD13184948
• Codice UNSPSC: 12352108
• ID PubChem: 329823930
• NACRES: NA.22

Proprietà

• Saggio: >90%
• Forma fisica: solid or viscous liquid
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: cross-linking reagent; reaction type: click chemistry
• Gruppo funzionale: NHS ester; azide
• Architettura del polimero: shape: linear; functionality: heterobifunctional
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN=[N+]=[N-]
• InChI: 1S/C15H24N4O8/c16-18-17-4-6-24-8-10-26-12-11-25-9-7-23-5-3-15(22)27-19-13(20)1-2-14(19)21/h1-12H2; OIGKWPIMJCPGGD-UHFFFAOYSA-N

Descrizione

Caratteristiche e vantaggi

The azido-dPEG^®₄-NHS ester contains an azide function on one end of a single molecular weight dPEG^® spacer (17.7 Å) and a reactive group on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. NHS ester readily reacts with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Note legali

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable