902578

Hydroxy-PEG6-t-butyl ester

≥95%

• Sinonimo/i: tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate, HO-PEG6-CO-OtBu
• Formula empirica (notazione di Hill): C₁₉H₃₈O₉
• Numero CAS: 361189-64-2
• Peso molecolare: 410.50
• Codice UNSPSC: 51171641
• NACRES: NA.22

Proprietà

• Saggio: ≥95%
• Forma fisica: liquid
• Impiego in reazioni chimiche: reagent type: cross-linking reagent
• Indice di rifrazione: n/D 1.454
• Densità: 1.068
• Gruppo funzionale: ester; hydroxyl
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
• InChI: 1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3; VGGDPFAYSOSIOK-UHFFFAOYSA-N

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Altre note

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Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable