901565

Propargyl-PEG₃-acid

• Formula empirica (notazione di Hill): C₁₀H₁₆O₅
• Numero CAS: 1347760-82-0
• Peso molecolare: 216.23
• Numero MDL: MFCD22201521
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Forma fisica: liquid
• Impiego in reazioni chimiche: reagent type: linker
• Gruppo funzionale: alkyne; carboxylic acid
• Temperatura di conservazione: −20°C
• Stringa SMILE: C#CCOCCOCCOCCC(O)=O

Descrizione

Applicazioni

Propargyl-PEG₃-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₃-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains three PEG units to help improve solubility.

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3