902667

Propargyl-PEG6-acid

• Sinonimo/i: 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• Formula empirica (notazione di Hill): C₁₆H₂₈O₈
• Numero CAS: 1951438-84-8
• Peso molecolare: 348.39
• Numero MDL: MFCD28950778
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Saggio: ≥95%
• Stato: liquid
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: cross-linking reagent
• Indice di rifrazione: n/D 1.469
• Gruppo funzionale: alkyne; carboxylic acid
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(CCOCCOCCOCCOCCOCCOCC#C)=O
• InChI: 1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18); XRSJYQQOJNYUDV-UHFFFAOYSA-N

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable