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品質等級
化驗
≥98%
分子量
481.3
儲存溫度
−20°C
SMILES 字串
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
InChI
1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChI 密鑰
SGIWFELWJPNFDH-UHFFFAOYSA-N
基因資訊
human ... ABCA1(19) , NR1H2(7376) , NR1H3(10062)
應用
T0901317应用于LXR激动剂研究，以观察小鼠所有受膳食胆固醇调节的基因的表达。此外，它还用于刺激WT（野生型）和Tg（转基因）小鼠放射性标记的腹腔巨噬细胞，以便进行细胞胆固醇流出测定。
生化／生理作用
T0901317能通过作用于线粒体代谢来阻止胰岛素的分泌。
LXR激动剂，其治疗导致ABC1基因表达的LXR依赖性上调
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Yan Xing et al.
Scientific reports, 6, 21309-21309 (2016-02-19)
Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on the capillarization of liver sinusoidal endothelial cells (LSECs) in liver fibrosis remain undetermined. Here
The LXR ligand T0901317 acutely inhibits insulin secretion by affecting mitochondrial metabolism
Maczewsky J, et al.
Endocrinology, 158(7), 2145-2154 (2017)
Differential Gene Regulation of StarD4 and StarD5 Cholesterol Transfer Proteins ACTIVATION OF StarD4 BY STEROL REGULATORY ELEMENT-BINDING PROTEIN-2 AND StarD5 BY ENDOPLASMIC RETICULUM STRESS
Soccio RE, et al.
The Journal of Biological Chemistry, 280(19), 19410-19418 (2005)
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
Maxwell KN, et al.
Journal of Lipid Research, 44(11), 2109-2119 (2003)
Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis
Yamada S, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(5), 994-1006 (2018)
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