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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: ≥5 mg/mL (warmed)
儲存溫度
−20°C
SMILES 字串
Cc1cc2c(cc1C3(CC3)c4ccc(cn4)C(O)=O)C(C)(C)CCC2(C)C
InChI
1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
InChI 密鑰
SLXTWXQUEZSSTJ-UHFFFAOYSA-N
生化／生理作用
LG100268（LG268）是一种有效的选择性类视色素和类视色素 X 受体（RXR）激动剂。Lg100268 与 α，β 和 γ RXR 受体结合，IC50 = 3-4 nM，且对 RAR 视黄酸受体无活性。
特點和優勢
该化合物在受体分类和信号转导手册中 核受体（非甾体化合物） 页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Janine Gericke et al.
PloS one, 8(4), e62643-e62643 (2013-05-03)
Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases. The present study used topical application of selective agonists and antagonists
Michael D Rush et al.
Journal of the American Society for Mass Spectrometry, 28(3), 479-485 (2016-12-15)
To overcome limiting factors in mass spectrometry-based screening methods such as automation while still facilitating the screening of complex mixtures such as botanical extracts, magnetic microbead affinity selection screening (MagMASS) was developed. The screening process involves immobilization of a target
Thi Xoan Hoang et al.
BioMed research international, 2019, 8059312-8059312 (2020-01-18)
All-trans retinoic acid (ATRA), an active form of vitamin A, exerts immunomodulatory functions. In this study, we examined the immune potentiating effect of ATRA on bacterial flagellin-induced NF-κB activation and proinflammatory cytokine production in human monocytic cell line THP-1. ATRA
Hien Thi Vu et al.
BioMed research international, 2018, 5971080-5971080 (2018-09-19)
All-trans retinoic acid (ATRA) is an effective drug for the induction therapy of acute promyelocytic leukemia. However, the treatment is associated with adverse events such as retinoic acid syndrome (RAS) in some patients, whose histologic characteristics included organ infiltration by
Yihong Wan et al.
Journal of molecular endocrinology, 44(2), 135-142 (2009-10-24)
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a key transcriptional regulator of both lipid metabolism and inflammation. The importance of PPARgamma is accentuated by the widespread use of synthetic PPARgamma agonists, thiazolidinediones (such as rosiglitazone), as drugs for
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