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Merck

C8554

Sigma-Aldrich

绒毛膜促性腺激素 人

lyophilized powder, suitable for mouse embryo cell culture

别名:

HCG, 绒毛膜促性腺激素

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About This Item

CAS号:
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human urine

品質等級

無菌

aseptically processed

形狀

lyophilized powder

效力

≥5,000 I.U. per mg

分子量

37.9 kDa
apparent mol wt 37.9 kDa by SDS-PAGE

drug control

Home Office Schedule 4.2

技術

cell culture | embryo: suitable

雜質

HBV,HCV and HIV, tested negative

溶解度

H2O: 1 mL/vial
saline: 1 mL/vial

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

基因資訊

human ... CGA(1081)

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一般說明

由 92 个氨基酸 α 链组成的糖蛋白激素,与 LH、FSH 和 TSH 相同; 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生,负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生,其特征是游离 hCG β-链升高和高糖基化 hCG。
注意:根据糖基化程度的不同,实际分子量与理论值不同。该物质天然形式的理论分子量为 37.9kDa,且包含 2 个亚基:α = 14.9kDa(多肽部分 ~10.2kDa,碳水化合物部分 ~4.7kDa),β = 23.0kDa(多肽部分 ~16.0kDa,碳水化合物部分 ~7.0kDa)。参见 J. Biol. Chem. 248,6796-6827(1973)。

應用

推荐用于小鼠的超数排卵诱导。

生化/生理作用

Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.

象形圖

Health hazard

訊號詞

Warning

危險聲明

防範說明

危險分類

Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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