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一般說明
由 92 个氨基酸 α 链组成的糖蛋白激素,与 LH、FSH 和 TSH 相同; 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生,负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生,其特征是游离 hCG β-链升高和高糖基化 hCG。
生化/生理作用
人绒毛膜促性腺激素(hCG)可用作 PMSG 的替代品,以诱导实验动物排卵。 当通过静脉内(静脉注射),腹膜内(腹腔注射)或皮下(皮下注射)方法将 hCG 注射到实验动物中时,每个动物和每千克体重的 50% 动物的有效剂量(ED50)用括号括起来如下:
小鼠:静脉注射0.2 (7.7) I.U.;腹腔注射0.3 (11.5) I.U.;皮下注射0.7 (26.9) I.U.
叙利亚仓鼠:静脉注射1.0 (9.5) I.U.;腹腔注射1.8 (17.1) I.U.;皮下注射2.6 (24.8) I.U.
大鼠:静脉注射1.3 (4.6) I.U.;腹腔注射3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
使用 PMSG,每只动物和每千克体重(kg)的 ED50 值如下:
小鼠: 静脉注射0.8 (30.8) I.U.;腹腔注射2.0 (76.9) I.U.;皮下注射2.8 (107.7) I.U
叙利亚仓鼠: 静脉注射, 3.6 (34.3) I.U.;腹腔注射,8.0 (76.2) I.U.;皮下注射,13.2 (125.7) I.U.
大鼠: 静脉注射,6.0 (76.8) I.U.;腹腔注射,20.8 (73.0) I.U.;皮下注射,76.8 (269.5) I.U.
小鼠:静脉注射0.2 (7.7) I.U.;腹腔注射0.3 (11.5) I.U.;皮下注射0.7 (26.9) I.U.
叙利亚仓鼠:静脉注射1.0 (9.5) I.U.;腹腔注射1.8 (17.1) I.U.;皮下注射2.6 (24.8) I.U.
大鼠:静脉注射1.3 (4.6) I.U.;腹腔注射3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
使用 PMSG,每只动物和每千克体重(kg)的 ED50 值如下:
小鼠: 静脉注射0.8 (30.8) I.U.;腹腔注射2.0 (76.9) I.U.;皮下注射2.8 (107.7) I.U
叙利亚仓鼠: 静脉注射, 3.6 (34.3) I.U.;腹腔注射,8.0 (76.2) I.U.;皮下注射,13.2 (125.7) I.U.
大鼠: 静脉注射,6.0 (76.8) I.U.;腹腔注射,20.8 (73.0) I.U.;皮下注射,76.8 (269.5) I.U.
聯結
与 C2047 类似,但来自其他供应商。
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