L4513

[des-Gly¹⁰, D-Ala⁶]-LH-RH ethylamide acetate salt hydrate

≥97% (HPLC), powder

• 别名: Ethylamide Acetate, Ethylamide Acetate Salt, des-Gly¹⁰ LH-RH
• 经验公式（希尔记法）: C₅₆H₇₈N₁₆O₁₂ · xC₂H₄O₂ · yH₂O
• 分子量: 1167.32 (anhydrous free base basis)
• MDL號碼: MFCD11046043
• 分類程式碼代碼: 12352209
• PubChem物質ID: 329817410
• NACRES: NA.32

属性

• 化驗: ≥97% (HPLC)
• 形狀: powder
• UniProt登錄號: P01148; P13562; P30968; Q01776
• 儲存溫度: −20°C
• SMILES 字串: O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6
• InChI: 1S/C56H78N16O12.C2H4O2.H2O/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38;1-2(3)4;/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61);1H3,(H,3,4);1H2/t31-,38+,39+,40+,41+,42+,43+,44+,45+;;/m1../s1
• InChI 密鑰: YEEHIOYEWOESQR-PFHUABGLSA-N
• 基因資訊: mouse ... GNRH1(2796) , GNRHR(2798) ; rat ... GNRH1(14714) , GNRHR(14715)

说明

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Ala-Leu-Arg-Pro-NHEt

應用

[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate has been used:

• as an luteinizing hormone-releasing hormone (LHRH) agonist to synchronize a cohort of females rats
• to synchronize naturally cycling rats
• to induce ovulation as a gonadotropin-releasing hormone (GnRH) analogue and as a supplement in Galap extender to dilute qualified ejaculate

生化／生理作用

Potent LH-RH agonist in rats and mice; reversibly delays sexual maturation in rats, stimulates spawning activity in fish. GnRH ( gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360
• 防範說明: P201 - P308 + P313
• 危險分類: Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges