SAB4300434

Anti-PAK1/PAK2/PAK3 (Ab-423/402/421) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-CDKN1A antibody produced in rabbit, Anti-MGC130000 antibody produced in rabbit, Anti-PAK65 antibody produced in rabbit, Anti-p21 protein (Cdc42 / Rac)-activated kinase 1 / 2 / 3 antibody produced in rabbit
• Número MDL: MFCD02097133
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: 61-67 kDa; 68-74 kDa
• reactividad de especies: rat, human, mouse
• concentración: 1 mg/mL
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• isotipo: IgG
• secuencia del inmunógeno: (R-S-T-M-V)
• Nº de acceso NCBI: NP_001121638.1; NP_001122092.1; NP_002568.2
• Nº de acceso UniProt: Q13177
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PAK1(5058) , PAK2(5062) , PAK3(5063)

Descripción

Inmunógeno

Peptide sequence around aa. 421-425/400-404/419-423 (R-S-T-M-V), according to the proteins PAK1/PAK2/PAK3.

Características y beneficios

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Descripción de destino

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable