SAB4300135

Anti-phospho-PAK1/PAK2/PAK3 (pThr⁴²³/pThr⁴⁰²/pThr⁴²¹) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-ADE2 antibody produced in rabbit, Anti-CDKN1A antibody produced in rabbit, Anti-PAK65 antibody produced in rabbit
• Número MDL: MFCD02097133
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: 61-67 kDa; 68-74 kDa
• reactividad de especies: mouse, human, rat
• concentración: 1 mg/mL
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• isotipo: IgG
• secuencia del inmunógeno: (R-S-TP-M-V)
• Nº de acceso NCBI: NP_001121638.1; NP_001122092.1; NP_002568.2
• Nº de acceso UniProt: Q13177
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pThr423/pThr402/pThr421)
• Información sobre el gen: human ... PAK1(5058) , PAK2(5062) , PAK3(5063)

Descripción

Inmunógeno

Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V), according to the protein PAK1/PAK2/PAK3.

Características y beneficios

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Descripción de destino

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable