Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

I5403

Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-2 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

Sinónimos:

IGFBP-2

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Número MDL:
MFCD02099094
Código UNSPSC:
51111800
NACRES:
NA.32

origen biológico

human

Nivel de calidad

100

recombinante

expressed in NSO cells

Análisis

≥95% (SDS-PAGE)

formulario

lyophilized powder

potencia

0.04 μg/mL

mol peso

~36 kDa by SDS-PAGE
calculated mol wt ~31 kDa

envase

pkg of 25 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell culture | mammalian: suitable

impurezas

endotoxin, tested

Nº de acceso UniProt

P18065

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IGFBP2(3485)

Descripción general

The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.

Acciones bioquímicas o fisiológicas

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.

Forma física

Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA

Nota de análisis

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H319,H332

Clasificaciones de peligro

Acute Tox. 4 Inhalation - Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Soo Hyun Park et al.
Investigative ophthalmology & visual science, 56(12), 7293-7302 (2015-11-13)
Previously, we reported that keratocyte-conditioned medium (KCM) facilitates the differentiation of human mesenchymal stem cells (hMSCs) into corneal keratocyte-like cells. This study is designed to investigate the roles of insulin-like growth factor binding protein 2 (IGFBP2) for the regulation of
Chad P Garner et al.
Human genetics, 123(3), 247-255 (2008-01-23)
The insulin-like growth factor (IGF) signaling pathway is thought to play a major role in the etiology of breast cancer. Although incidence rates of breast cancer overall are lower in African Americans than in Caucasians, African-American women have a higher
H Yu et al.
Journal of clinical laboratory analysis, 13(4), 166-172 (1999-07-22)
Insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) play an important role in cell growth and differentiation. Clinical and epidemiological studies have indicated that measuring IGFs and IGFBPs in blood has potential implications in assessing growth-related abnormalities and risks
K M Kelley et al.
The international journal of biochemistry & cell biology, 28(6), 619-637 (1996-06-01)
The IGFBPs are a family of homologous proteins that have co-evolved with the IGFs and that confer upon the IGF regulatory system both functional and tissue specificity. IGFBPs are not merely carrier proteins for IGFs, but hold a central position

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico