V5765
Vascular Endothelial Growth Factor 165 human
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in HEK 293 cells
Descrizione
Vascular Endothelial Growth Factor 165 human
Saggio
≥95% (SDS-PAGE)
Stato
lyophilized powder
Potenza
<10 ng/mL ED50
Qualità
endotoxin tested
PM
dimer 42 kDa (glycosylated)
Confezionamento
pkg of 10 μg
pkg of 50 μg
tecniche
cell culture | mammalian: suitable
Impurezze
<0.075 EU/μg
Colore
white
Solubilità
water: soluble
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... VEGFA(7422)
Descrizione generale
VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Azioni biochim/fisiol
VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
Risultati analitici
The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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