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Key Documents

T4571

SAFC

Taurina

Sinonimo/i:

Acido 2-amminoetanosolfonico

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About This Item

Formula condensata:
NH2CH2CH2SO3H
Numero CAS:
Peso molecolare:
125.15
Beilstein:
1751215
Numero CE:
Numero MDL:
Codice UNSPSC:
12352106
NACRES:
NA.26

Origine biologica

non-animal source

Saggio

≥98.5%

Forma fisica

crystalline powder

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, heavy metals, trace metals, tested

Punto di fusione

>300 °C (lit.)

Solubilità

H2O: ≥100 mg/mL

Attività estranea

cytotoxicity, tested

Stringa SMILE

NCCS(O)(=O)=O

InChI

1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)
XOAAWQZATWQOTB-UHFFFAOYSA-N

Informazioni sul gene

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Descrizione generale

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to documentation for this product requires a confidentiality disclosure agreement.

Applicazioni

Taurine is a derivative of the sulfur-containing (sulfhydryl) amino acid cysteine. Taurine is one of the few known naturally occurring sulfonic acids. It is a conditionally essential sulfonated amino acid which modulates apoptosis in some cells; functions in many metabolic activities; a product of methionine and cysteine metabolism. It can be used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Azioni biochim/fisiol

Agonista endogeno non selettivo dei recettori della glicina. Amminoacido solfonato condizionatamente essenziale, modula l′apoptosi in alcune cellule, partecipa a molte attività metaboliche; è un prodotto del metabolismo di metionina e cisteina.

Note legali

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Takashi Ito et al.
Journal of molecular and cellular cardiology, 44(5), 927-937 (2008-04-15)
The sulfur-containing beta-amino acid, taurine, is the most abundant free amino acid in cardiac and skeletal muscle. Although its physiological function has not been established, it is thought to play an important role in ion movement, calcium handling, osmoregulation and
Tsutomu Suzuki et al.
Wiley interdisciplinary reviews. RNA, 2(3), 376-386 (2011-10-01)
Mitochondrial DNA mutations that cause mitochondrial dysfunction are responsible for a wide spectrum of human diseases, referred to as mitochondrial diseases. Pathogenic point mutations are found frequently in genes encoding mitochondrial (mt) tRNAs, indicating that impaired functioning of mutant mt
M Axelson et al.
Hepatology (Baltimore, Md.), 31(6), 1305-1312 (2000-05-29)
The biosynthesis of bile acids by primary cultures of normal human hepatocytes has been investigated. A general and sensitive method for the isolation and analysis of sterols and bile acids was used, based on anion exchange chromatography and gas chromatography-mass
Marlene Wewalka et al.
The Journal of clinical endocrinology and metabolism, 99(4), 1442-1451 (2014-01-18)
Bile acids (BAs) are newly recognized signaling molecules in glucose and energy homeostasis. Differences in BA profiles with type 2 diabetes mellitus (T2D) remain incompletely understood. The objective of the study was to assess serum BA composition in impaired glucose-tolerant
Deniz Tasdemir et al.
Bioorganic & medicinal chemistry, 15(21), 6834-6845 (2007-09-04)
The type II fatty acid pathway (FAS-II) is a validated target for antimicrobial drug discovery. An activity-guided isolation procedure based on Plasmodium falciparum enoyl-ACP reductase (PfFabI) enzyme inhibition assay on the n-hexane-, the CHCl(3-) and the aq MeOH extracts of

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