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Key Documents

SML1845

Sigma-Aldrich

Thapsigargin Ready Made Solution

≥98% (HPLC), 10 mM in DMSO

Sinonimo/i:

CHEBI:9516, CHEMBL96926, MFCD00083511, UNII-Z96BQ26RZD, Z96BQ26RZD, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate

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About This Item

Formula empirica (notazione di Hill):
C34H50O12
Numero CAS:
Peso molecolare:
650.75
Codice UNSPSC:
12352200
NACRES:
NA.77

Origine biologica

(Thapsia garganica L seeds)

Livello qualitativo

Saggio

≥98% (HPLC)

Forma fisica

DMSO solution

Concentrazione

10 mM in DMSO

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

InChI

1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
IXFPJGBNCFXKPI-FSIHEZPISA-N

Applicazioni

Thapsigargin Ready Made Solution has been used as a negative control in in vivo growth and in vitro translation measurements.

Azioni biochim/fisiol

Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues. The inhibition of calcium ion pumps causes intracellular increase of calcium ion levels. It was found that thapsigargin at 100 nM concentration effectively inhibited the SR Ca2+- adenosine triphosphatase (ATPase) in cardiac and skeletal muscles. Thapsigargin was also reported to be effective in blocking autophagy by interfering with the autophagosome-lysosome fusion.
Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues.

Altre note

Thapsigargin Ready Made Solution is provided at 10 mM concentration in DMSO. The solution can be further diluted with DMSO to a concentration of 2 mM. It is recommended to store Thapsigargin Ready Made Solution in small aliquots at -20 °C.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

188.6 °F - closed cup

Punto d’infiammabilità (°C)

87 °C - closed cup


Certificati d'analisi (COA)

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Y Kijima et al.
The Journal of biological chemistry, 266(34), 22912-22918 (1991-12-05)
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Spike timing-dependent plasticity (STDP) is a Hebbian learning rule important for synaptic refinement during development and for learning and memory in the adult. Given the importance of the hippocampus in memory, surprisingly little is known about the mechanisms and functions
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Malaria Journal, 465-465 (2018)
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<BIG>Ganley IG, et al..</BIG>
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