P0106

Pefloxacin

• Sinonimo/i: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate, Pefloxacine monomethanesulfonate dihydrate, Pefloxacinium methanesulfonate dihydrate
• Formula condensata: C₁₇H₂₀FN₃O₃ • CH₄O₃S • 2H₂O
• Numero CAS: 149676-40-4
• Peso molecolare: 465.49
• Numero CE: 274-613-9
• Numero MDL: MFCD01685696
• Codice UNSPSC: 51102829
• ID PubChem: 329820015
• NACRES: NA.76

Proprietà

• Stato: powder
• Livello qualitativo: 100
• Solubilità: H₂O: 50 mg/mL
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: DNA synthesis | interferes; enzyme | inhibits
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
• InChI: 1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2; LEULAXMUNMRLPW-UHFFFAOYSA-N

Descrizione

Descrizione generale

Chemical structure: fluoroquinolone

Applicazioni

Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes.

Azioni biochim/fisiol

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H319
• Consigli di prudenza: P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves