N9037

Necrostatin-1

≥98% (HPLC), powder, necroptosis inhibitor

• Sinonimo/i: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, 5-(Indol-3-ylmethyl)-3-methyl-2-thio-Hydantoin, MTH-DL-Tryptophan
• Formula empirica (notazione di Hill): C₁₃H₁₃N₃OS
• Numero CAS: 4311-88-0
• Peso molecolare: 259.33
• Numero MDL: MFCD00056916
• Codice UNSPSC: 12352200
• ID PubChem: 24724559
• NACRES: NA.77

Proprietà

• product name: Necrostatin-1, ≥98% (HPLC)
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Solubilità: DMSO: >10 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
• InChI: 1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18); TXUWMXQFNYDOEZ-UHFFFAOYSA-N

Descrizione

Applicazioni

Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro. It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.

Azioni biochim/fisiol

Necrostatin-1(Nec-1) might exhibit therapeutic benefit against patients with traumatic brain injury (TBI). In addition, it might also be used to treat other acute central nervous system (CNS) disorders that feature necroptosis as a mode of cell death. It is extensively used to study the effect of receptor-interacting protein kinase 1 (RIPK1) on cell death and inflammation in experimental disease models. Nec‐1 protects hippocampal (HT‐22) cells from glutamate‐induced oxytosis via increasing cellular glutathione (GSH) levels, decreasing reactive oxygen species production, inhibiting the nuclear translocation of apoptosis‐inducing factor and B-cell lymphoma 2 (Bcl‐2) /adenovirus E1B 19kDa‐interacting protein 3‐related pathways.

Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway).

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)