SML0583

Ferrostatin-1

≥95% (HPLC), powder, non-apoptotic cell death inhibitor

• Sinonimo/i: 3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
• Formula empirica (notazione di Hill): C₁₅H₂₂N₂O₂
• Numero CAS: 347174-05-4
• Peso molecolare: 262.35
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• product name: Ferrostatin-1, ≥95% (HPLC)
• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: powder
• Colore: , faint purple to brown
• Solubilità: DMSO: 10 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3; UJHBVMHOBZBWMX-UHFFFAOYSA-N

Descrizione

Applicazioni

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.

Azioni biochim/fisiol

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.

Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable