F132

Fluoxetine hydrochloride

≥98% (TLC), solid, selective serotonin reuptake inhibitor 

• Sinonimo/i: Fluoxetine HCl, (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac^®
• Formula empirica (notazione di Hill): C₁₇H₁₈F₃NO · HCl
• Numero CAS: 56296-78-7
• Peso molecolare: 345.79
• Numero CE: 260-101-2
• Numero MDL: MFCD00214288
• Codice UNSPSC: 12352200
• ID PubChem: 24278096
• NACRES: NA.77

Proprietà

• product name: Fluoxetine hydrochloride, solid
• Forma fisica: solid
• Livello qualitativo: 200
• Colore: white
• Solubilità: H₂O: 4 mg/mL; DMSO: >5 mg/mL
• Ideatore: Eli Lilly
• Stringa SMILE: CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl
• InChI: 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H; GIYXAJPCNFJEHY-UHFFFAOYSA-N
• Informazioni sul gene: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Descrizione

Descrizione generale

Fluoxetine hydrochloride is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac^®.

Applicazioni

Fluoxetine hydrochloride has been used to study its effect on the binding ability of the radiopharmaceutical 123I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (^[123I]ADAM) to SERT (serotonin transporters) in mice. It has also been used for the chronic treatment of light deprived animals.It has also been used as a serotonin reuptake inhibitor to study its effects on acute stress in fish.

Azioni biochim/fisiol

Fluoxetine hydrochloride works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.

Selective serotonin reuptake inhibitor; antidepressant.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Sold under license from Eli Lilly and Company.

Prozac is a registered trademark of Eli Lilly and Co.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS05,GHS07,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H318,H336,H373,H410
• Consigli di prudenza: P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves