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C-045

Supelco

Cannabidiolo

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Sinonimo/i:

CBD

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About This Item

Formula empirica (notazione di Hill):
C21H30O2
Numero CAS:
13956-29-1
Peso molecolare:
314.46
Numero CE:
200-659-6
Numero MDL:
MFCD00869597
Codice UNSPSC:
41116107
ID PubChem:
329774791
NACRES:
NA.24

Grado

certified reference material

Livello qualitativo

300

Forma fisica

liquid

Caratteristiche

SNAP-N-SPIKE®, SNAP-N-SHOOT®

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

Concentrazione

1.0 mg/mL in methanol

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

cannabis testing
cannabis testing

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1

InChI

1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
QHMBSVQNZZTUGM-ZWKOTPCHSA-N

Informazioni sul gene

human ... CNR1(1268)

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Categorie correlate

Descrizione generale

Questa soluzione di spiking certificata (Certified Spiking Solution®) è adatta all′analisi del cannabidiolo mediante tecniche HPLC, GC/MS o LC-MS/MS in applicazioni di analisi forense, tossicologia clinica, ricerca di sostanze psicoattive nelle urine o caratterizzazione della potenza e del profilo delle impurezze della Cannabis.

Il cannabidiolo (CBD) è uno dei cannabinoidi di rilievo presenti nelle piante della famiglia delle Cannabaceae noto per le sue proprietà non psicoattive. Si forma in presenza di luce o di una fonte di calore per decarbossilazione del suo precursore, l′acido cannabidiolico. Mostra diverse proprietà terapeutiche, come per esempio proprietà antiossidanti, antinfiammatorie, antibatteriche, neuroprotettive, ansiolitiche e anticonvulsivanti.

Applicazioni

Il materiale di riferimento certificato (CRM) in soluzione può essere utilizzato anche per i seguenti scopi:
  • Determinazione di quattro cannabinoidi in una matrice di olio mediante cromatografia liquida ad alte prestazioni a fase inversa (RP-HPLC) con rivelatore a serie di diodi (DAD)
  • Sviluppo e validazione di una tecnica di cromatografia liquida-spettrometria di massa tandem (LC-MS/MS) per la misurazione di cannabidiolo, ∆9-tetraidrocannabinolo e i suoi metaboliti in campioni di sangue intero di topi cui è stata somministrata una dose elevata di cannabidiolo
  • Determinazione simultanea di cannabidiolo e tetraidrocannabidiolo in differenti prodotti contenenti olio di canapa mediante RP-HPLC isocratica con rivelatore UV
  • Analisi multipla di campioni di capelli per la determinazione di Δ9-tetraidrocannabinolo, cannabinolo e cannabidiolo per estrazione liquido-liquido (LLE) seguita da quantificazione mediante gascromatografia-spettrometria di massa
  • Estrazione assistita da ultrasuoni di cannabidiolo da tre diversi prodotti topici commerciali seguita da determinazione mediante GC-MS

Caratteristiche e vantaggi

  • Caratterizzato in modo esauriente da strutture accreditate ISO/IEC 17025 e ISO 17034
  • Accompagnato da un certificato di analisi (CoA) completo che riporta i dati sulla stabilità, l′omogeneità, l′accuratezza della concentrazione, le incertezze di misura e la tracciabilità
  • Sottoposto a rigorose analisi mediante studi di stabilità in tempo reale per garantire accuratezza e determinare la vita di scaffale
  • Preparato gravimetricamente utilizzando bilance di precisione qualificate per un′incertezza di misura minima
  • Sigillato alla fiamma in fiale sotto atmosfera inerte di argon per una vita di scaffale di lungo termine
  • Proposto in un formato pratico, esente DEA, per migliorare l′efficienza del laboratorio

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Avvertenze

Danger

Indicazioni di pericolo

H225,H301 + H311 + H331,H370

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organi bersaglio

Eyes,Central nervous system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

49.5 °F - closed cup

Punto d’infiammabilità (°C)

9.7 °C - closed cup

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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R B Laprairie et al.
British journal of pharmacology, 172(20), 4790-4805 (2015-07-29)
Cannabidiol has been reported to act as an antagonist at cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid agonist activity through negative allosteric modulation of CB1 receptors. Internalization of CB1 receptors, arrestin2 recruitment, and PLCβ3 and ERK1/2 phosphorylation
Raymond J M Niesink et al.
Addiction (Abingdon, England), 110(12), 1941-1950 (2015-08-04)
Between 2000 and 2005 the average percentage of Δ(9) -tetrahydrocannabinol (THC) in marijuana as sold in Dutch coffeeshops has increased substantially; the potency of domestic products (Nederwiet and Nederhasj) has particularly increased. In contrast with imported marijuana, Nederwiet hardly contained
Amir Englund et al.
Journal of psychopharmacology (Oxford, England), 27(1), 19-27 (2012-10-09)
Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue because THC and CBD can be administered in pure
Javier Fernández-Ruiz et al.
British journal of clinical pharmacology, 75(2), 323-333 (2012-05-26)
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anxiolytic and antipsychotic agent, and is
Marcos Hortes N Chagas et al.
Journal of psychopharmacology (Oxford, England), 27(3), 312-316 (2013-01-25)
Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle. The objective of this paper is to assess the effects on sleep of acute systemic administration
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