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Key Documents

1500218

USP

Paroxetine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Sinonimo/i:

Paroxetine hydrochloride hemihydrate, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

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About This Item

Formula empirica (notazione di Hill):
C19H20FNO3 · HCl · .5 H2O
Numero CAS:
Peso molecolare:
374.83
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

paroxetine

Produttore/marchio commerciale

USP

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1
QRQSGFFISBKLMZ-YHOFXEKLSA-N

Informazioni sul gene

human ... SLC6A4(6532)

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Descrizione generale

Paroxetine hydrochloride is a phenylpiperidine derivative which is selective serotonin reuptake inhibitor. The protein binding ability is high. It has 2 forms, non-hygroscopic hemihydrate and hygroscopic anhydrate. This drug is seen useful in treating premature ejaculation in men.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Paroxetine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Azioni biochim/fisiol

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

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Pittogrammi

Exclamation markEnvironment

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Perinatal outcome following third trimester exposure to paroxetine.
Costei, Adriana Moldovan, et al.
Archives of Pediatrics & Adolescent Medicine, 156.11, 1129-1132 (2002)
C G McMahon et al.
International journal of impotence research, 11(5), 241-245 (1999-12-20)
To evaluate the efficacy of chronic and 'on demand' administration of paroxetine hydrochloride in the drug treatment of premature ejaculation (PE). Ninety-four normally potent men, aged 18-61 y (mean 39 y) with premature ejaculation were treated between January 1996 and
Solid-state forms of paroxetine hydrochloride.
Buxton, P. Christopher, Ian R. Lynch, and John M. Roe.
International Journal of Pharmaceutics, 42.1, 135-143 (1988)
E Di Girolamo et al.
Journal of the American College of Cardiology, 33(5), 1227-1230 (1999-04-08)
The purpose of the study was to determine whether the well tolerated serotonin reuptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in patients resistant to or intolerant of previous traditional therapies. Serotonergic mechanisms play a major role in the processes
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A novel SiX-dipropargyl glycerol scaffold (X: H, F, or (18) F) was developed as a versatile prosthetic group that provides technical advantages for the preparation of dimeric radioligands based on silicon fluoride acceptor pre- or post-labeling with fluorine-18. Rapid conjugation

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