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Key Documents

PHR1307

Supelco

Captopril

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline

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About This Item

Formula empirica (notazione di Hill):
C9H15NO3S
Numero CAS:
Peso molecolare:
217.29
Beilstein:
477887
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to BP 538
traceable to Ph. Eur. C0430000
traceable to USP 1091200

Famiglia di API

captopril

CdA

current certificate can be downloaded

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

104-108 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
FAKRSMQSSFJEIM-RQJHMYQMSA-N

Informazioni sul gene

human ... ACE(1636)

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Descrizione generale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Captopril acts by inhibiting the angiotensin-converting enzyme and is known as an antihypertensive agent. It finds wide use in the treatment of congestive heart failure.

Applicazioni

Captopril may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Azioni biochim/fisiol

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA0067 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pittogrammi

Health hazard

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Muta. 2 - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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Sigma-Aldrich

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Lisinopril

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Supelco

16587

Daidzein

Potentiometric determination of captopril in pharmaceutical formulations
Ribeiro PRDS, et al.
Ecletica Quimica, 28(1), 39-44 (2003)
Square-wave voltammetric (SWV) determination of Captopril in reconstituted serum and pharmaceutical formulations
Parham H and Zargar B
Talanta, 65(3), 776-780 (2005)
Validation of simultaneous volumetric and spectrophotometric methods for the determination of captopril in pharmaceutical formulations
Rahman N, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(6-7), 569-574 (2005)
Determination of captopril and its degradation products by capillary electrophoresis
Hillaert S and Van den Bossche W
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 65-73 (1999)
Analysis of captopril and hydrochlorothiazide combination tablet formulations by liquid chromatography
Kirschbaum J and Perlman S
Journal of Pharmaceutical Sciences, 73(5), 686-687 (1984)

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