C4042

Captopril

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

• Sinonimo/i: N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
• Formula empirica (notazione di Hill): C₉H₁₅NO₃S
• Numero CAS: 62571-86-2
• Peso molecolare: 217.29
• Beilstein: 477887
• Numero CE: 263-607-1
• Numero MDL: MFCD00168073
• Codice UNSPSC: 12352200
• ID PubChem: 57654003
• NACRES: NA.77

Proprietà

• Nome del prodotto: Captopril, ≥98% (HPLC), powder
• Origine biologica: synthetic
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to off-white
• Punto di fusione: 104-108 °C (lit.)
• Solubilità: water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• Ideatore: Bristol-Myers Squibb
• Temperatura di conservazione: room temp
• Stringa SMILE: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1; FAKRSMQSSFJEIM-RQJHMYQMSA-N
• Informazioni sul gene: human ... ACE(1636) , AGTR1(185) , AGTR2(186) , ECE1(1889) ; rat ... Ace(24310)

Descrizione

Applicazioni

Captopril has been used:

• to examine the influence of timing of captopril treatment on efficacy in transverse aortic constriction (TAC) mice
• as an angiotensin-converting enzyme inhibitor and orally administered to unrestrained Wistar Kyoto rats in an approach to study its effects of angiogenesis inhibition and interdependency with other drugs
• used as a positive control in spectrophotometric assay to study the angiotensin-converting enzyme inhibitory activity

Azioni biochim/fisiol

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Captopril is known to decrease the cardiovascular complications arising due to myocardial infarction. It is an effective drug in treating diabetic nephropathy and renal disease. Captopril acts by reducing cardiac related inflammation, fibrosis and calcification.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H341,H360F
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Muta. 2 - Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges