T6031

DL-Thiorphan

≥98% (TLC)

• Sinonimo/i: (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine
• Formula empirica (notazione di Hill): C₁₂H₁₅NO₃S
• Numero CAS: 76721-89-6
• Peso molecolare: 253.32
• Beilstein: 4872101
• Numero MDL: MFCD00058435
• Codice UNSPSC: 12352200
• ID PubChem: 24278747
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Forma fisica: powder
• Punto di fusione: 138 °C
• Solubilità: ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
• Stringa SMILE: OC(=O)CNC(=O)C(CS)Cc1ccccc1
• InChI: 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15); LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• Informazioni sul gene: human ... ACE(1636) , ECE1(1889) ; rat ... Ace(24310) , Mme(24590)

Descrizione

Descrizione generale

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)

Applicazioni

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

Azioni biochim/fisiol

Enkephalinase inhibitor.

Caratteristiche e vantaggi

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)