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MME

membrane metallo-endopeptidase

Synonyms:
CALLA, CD10, NEP, SFE
Species:
UniProtKB ID:
Gene ID:
  • Human(4311) Summary: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
  • Mouse(17380) membrane metallo endopeptidase
  • Rat(24590) membrane metallo-endopeptidase
  • chicken(425031) membrane metallo-endopeptidase
  • dog(477120) membrane metallo-endopeptidase
  • cow(536741) membrane metallo-endopeptidase
  • Horse(100053541) membrane metallo-endopeptidase
  • domestic cat(101087516) membrane metallo-endopeptidase
  • sheep(101112618) membrane metallo-endopeptidase
  • domestic guinea pig(100724320) membrane metallo-endopeptidase
  • naked mole-rat(101715828) membrane metallo-endopeptidase
  • Domestic Rabbit(100009251) membrane metallo-endopeptidase

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ELISA

Product Number
Description
Species
Mouse Mme / Neprilysin ELISA Kit, ,
Species
mouse
Human MME / Neprilysin ELISA, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep), serum, Chemicon®,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-CD10 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM337, purified immunoglobulin,
Species Reactivity
human
Application
immunohistochemistry
ANTI-NEPRILYSIN(C-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry

western blot
Anti-MME antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-MME antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
DL-Thiorphan, ≥98% (TLC),
Species
human, rat
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine, 97%,
Species
human, mouse, rat

Proteins

Product Number
Description
Species
Neprilysin/CD10 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MME,
Species
human
MISSION® esiRNA, targeting mouse Mme,
Species
mouse