917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

• Sinonimo/i: Semi-flexible linker for PROTAC^® development
• Formula empirica (notazione di Hill): C₁₂H₁₈ClNO
• Numero CAS: 1187927-60-1
• Peso molecolare: 227.73
• Numero MDL: MFCD11506185
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Stato: powder
• Impiego in reazioni chimiche: reagent type: linker
• Gruppo funzionale: hydroxyl
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OCC1=CC=C(C2CCNCC2)C=C1.Cl
• InChI: 1S/C12H17NO.ClH/c14-9-10-1-3-11(4-2-10)12-5-7-13-8-6-12;/h1-4,12-14H,5-9H2;1H; JSCRYCUDRVBGRN-UHFFFAOYSA-N

Descrizione

Applicazioni

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Altre note

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable