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916617

Sigma-Aldrich

2-(3-(Piperidin-4-yl)phenyl)acetic acid hydrochloride

≥95%

Sinonimo/i:

Semi-flexible linker for PROTAC® development

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About This Item

Formula empirica (notazione di Hill):
C13H18ClNO2
Peso molecolare:
255.74
Codice UNSPSC:
12352106

Livello qualitativo

100

Saggio

≥95%

Forma fisica

powder

Impiego in reazioni chimiche

reagent type: linker

Gruppo funzionale

carboxylic acid

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C(CC1=CC(C2CCNCC2)=CC=C1)O.Cl

Applicazioni

2-(3-(Biperidin-4-yl)phenyl)acetic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Altre note

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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