Passa al contenuto
Merck
Tutte le immagini(2)

Key Documents

View All Documentation

916870

Sigma-Aldrich

4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid

≥95%

Sinonimo/i:

Semi-flexible linker for PROTAC® development

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(2)

About This Item

Formula empirica (notazione di Hill):
C17H23NO4
Numero CAS:
149353-75-3
Peso molecolare:
305.37
Numero MDL:
MFCD02178897
Codice UNSPSC:
12352106

Livello qualitativo

100

Saggio

≥95%

Forma fisica

powder

Impiego in reazioni chimiche

reagent type: linker

Gruppo funzionale

Boc
carboxylic acid

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C(N(CC1)CCC1C(C=C2)=CC=C2C(O)=O)OC(C)(C)C

InChI

1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-13(9-11-18)12-4-6-14(7-5-12)15(19)20/h4-7,13H,8-11H2,1-3H3,(H,19,20)
YCNVQGGUCDVTIZ-UHFFFAOYSA-N

Applicazioni

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Altre note

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

917605

2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

917362

2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid, ≥95%

917125

tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917109

2-(3-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid

917869

2-(2-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

916617

2-(3-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

916633

(3-(Piperidin-4-yl)phenyl)methanamine dihydrochloride, ≥95%

917591

tert-Butyl 4-(3-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

916889

tert-Butyl 4-(4-(2-aminoethyl)phenyl)piperidine-1-carboxylate, ≥95%

916900

2-(3-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916641

2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride, 95%

917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

916854

2-(Piperidin-4-yl)benzoic acid hydrochloride, 95%

917907

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride, ≥95%

917095

4-(Piperidin-4-yl)benzoic acid hydrochloride, ≥95%

917893

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

917656

3-(Piperidin-4-yl)benzoic acid hydrochloride, ≥95%

917168

tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917397

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

917419

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

917354

tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate

917141

2-(4-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916625

tert-Butyl 4-(3-(2-aminoethyl)phenyl)piperidine-1-carboxylate, ≥95%

917915

2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid, ≥95%

917133

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride, ≥95%

917400

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917664

2-(2-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916897

(3-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

916846

2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid, 95%

916595

tert-Butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

916587

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid, ≥95%

917850

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

Pittogrammi

Exclamation markEnvironment
GHS07,GHS09

Avvertenze

Warning

Indicazioni di pericolo

H315,H317,H319,H410

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

Ci dispiace, ma al momento non ci sono COA disponibili online per questo prodotto.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Weilin Sun et al.
Journal of medicinal chemistry, 62(6), 3122-3134 (2019-03-16)
Imatinib mesylate, 1a, inhibits production of β-amyloid (Aβ) peptides both in cells and in animal models. It reduces both the β-secretase and γ-secretase cleavages of the amyloid precursor protein (APP) and mediates a synergistic effect, when combined with a β-secretase
Andrei A Krysko et al.
Bioorganic & medicinal chemistry letters, 26(7), 1839-1843 (2016-02-26)
A series of 2-piperazin-1-yl-quinazolines were synthesized and evaluated for their antiaggregative activity. The synthesized small molecule compounds have potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to αIIbβ3 integrin in a suspension of washed human platelets. The key
Dillon T Flood et al.
Journal of the American Chemical Society, 141(25), 9998-10006 (2019-05-29)
DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity
Dominik K Kölmel et al.
ACS combinatorial science, 21(8), 588-597 (2019-07-10)
A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine ligand was key to the development of a

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.