648469-M

Troglitazone

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ).

• Sinonimo/i: Troglitazone
• Formula empirica (notazione di Hill): C₂₄H₂₇NO₅S
• Numero CAS: 97322-87-7
• Peso molecolare: 441.54
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white to yellow
• Solubilità: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Temperatura di conservazione: −20°C
• InChI: 1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28); GXPHKUHSUJUWKP-UHFFFAOYSA-N

Descrizione

Descrizione generale

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21^Cip1 turnover by inhibiting PKC_δ signaling in VSMCs. Exerts positive inotropic effect via Ca²⁺ sensitization in the sarcoplasmic reticulum and inhibits Na⁺/H⁺ exchange activity and proliferation of macrovascular endothelial cells.

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMCs) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21^cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca²⁺ sensitization in sarcoplasmic reticulum and inhibits Na⁺/H⁺ change activity.

Azioni biochim/fisiol

Primary Target
Peroxisome proliferator-activated receptors γ (PPARγ)

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.

Altre note

Masamune, A., et al. 2002. J. Biol. Chem.277, 141.
Boyault, S., et al. 2001. FEBS Lett.501, 24.
de Dios, S.T., et al. 2001. J. Diabetes Complications15, 120.
Furuse, Y., et al. 2001. Br. J. Pharmacol.133, 1307.
Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab.86, 1306.
Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol.38, 909.
Koga, H., et al. 2001. Hepatology33, 1087.
Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem.276, 37731.
Subbaramaiah, K., et al. 2001. J. Biol. Chem.276, 12440.
Takashima, T., et al. 2001. Int. J. Oncol.19, 465.
Takeda, K., et al. 2001. J. Biol. Chem.276, 48950.
Tanaka, T., et al. 2001. Cancer Res.61, 2424.
Wakino, S., et al. 2001. J. Biol. Chem.276, 47650.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable