554325

Resveratrol

≥98% (HPLC), solid, COX-1 inhibitor, Calbiochem^®

• Sinonimo/i: Resveratrol, trans-3,4ʹ,5-Trihydroxystilbene
• Formula empirica (notazione di Hill): C₁₄H₁₂O₃
• Numero CAS: 501-36-0
• Peso molecolare: 228.24
• Numero MDL: MFCD00133799
• Codice UNSPSC: 12191503
• NACRES: NA.77

Proprietà

• product name: Resveratrol, A phenolic product found in both grape skins and wines.
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: off-white
• Solubilità: DMSO: 50 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+; LUKBXSAWLPMMSZ-OWOJBTEDSA-N

Descrizione

Descrizione generale

A phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED₅₀ = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED₅₀ = 3.7 µM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED₅₀ = 27 µM) and acts as an anti-mutagenic agent (ED₅₀ = 15 µM) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED₅₀ = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED₅₀ = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED₅₀ = 27 µM) and acts as an anti-mutagenic agent (ED₅₀ = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

Azioni biochim/fisiol

Cell permeable: no

ED50 = 15 µM against COX-1

Primary Target
COX-1

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Howitz, K.T., et al. 2003. Nature425, 191.
Lin, H.Y., et al. 2002. J. Urol.168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H319
• Consigli di prudenza: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classi di pericolo: Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): >392.0 °F - closed cup - (External MSDS)
• Punto d’infiammabilità (°C): > 200.0 °C - closed cup - (External MSDS)