444300

Melatonin

A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals.

• Sinonimo/i: Melatonin, N-Acetyl-5-methoxytryptamine, 5-Methoxy-N-acetyltryptamine
• Formula empirica (notazione di Hill): C₁₃H₁₆N₂O₂
• Numero CAS: 73-31-4
• Peso molecolare: 232.28
• Numero MDL: MFCD00005655
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Descrizione: Merck USA index - 14, 5816
• Saggio: ≥98% (HPLC)
• Stato: powder
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white to slightly yellow
• Solubilità: methanol: 50 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [nH]1c2c(c(c1)CCNC(=O)C)cc(cc2)OC
• InChI: 1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16); DRLFMBDRBRZALE-UHFFFAOYSA-N

Descrizione

Descrizione generale

A hormone that has been postulated as being a mediator of photic-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Inhibits rat cerebellar nitric oxide synthase (NOS).

A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Exhibits antioxidant properties. Has neuroprotective effects against Aβ peptides. Inhibits rat cerebellar nitric oxide synthase (NOS). Also acts as a peroxynitrite scavenger.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
rat NOS

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstiution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Pappolla, M.A., et al. 2002. J. Pineal Res.32, 135.
Reiter, R.J., and Tan, D.X. 2002. Ann. N.Y. Acad. Sci.957, 341.
Cuzzocrea, S., et al. 1998. J. Pineal Res. 25, 24.
Maestroni, G.J., et al. 1994. Cancer Res. 54, 2429.
Pozo, D., et al. 1994. Life Sciences55, PL455.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable