QBD10503

Azido-dPEG^®₈-NHS ester

• Sinonimo/i: 2,5-Dioxo-1-pyrrolidinyl 3-[(23-azido-3,6,9,12,15,18,21-heptaoxatricos-1-yl)oxy]propanoate, Polyethylene glycol
• Formula empirica (notazione di Hill): C₂₃H₄₀N₄O₁₂
• Numero CAS: 1204834-00-3
• Peso molecolare: 564.58
• Numero MDL: MFCD13184949
• Codice UNSPSC: 12161502
• ID PubChem: 329823932
• NACRES: NA.22

Proprietà

• Saggio: >90%
• Stato: solid or viscous liquid
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: cross-linking reagent; reaction type: click chemistry
• Gruppo funzionale: NHS ester; azide
• Architettura del polimero: shape: linear; functionality: heterobifunctional
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
• InChI: AZXJVYAMFTUKFC-UHFFFAOYSA-N

Descrizione

Caratteristiche e vantaggi

The azido-dPEG^®₈-NHS ester contains an azide function on one end of a single molecular weight dPEG^® spacer(32.2 Å) and a reactive group (NHS ester) on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. N-hydroxysuccinimide (NHS) ester readily react with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Note legali

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable