902543

Propargyl-PEG4-acid

• Sinonimo/i: 4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH₂CO₂H
• Formula empirica (notazione di Hill): C₁₂H₂₀O₆
• Numero CAS: 1415800-32-6
• Peso molecolare: 260.28
• Numero MDL: MFCD22683284
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Stato: liquid
• Impiego in reazioni chimiche: reagent type: linker
• Disponibilità: available only in USA
• Indice di rifrazione: n/D 1.460
• Densità: 1.164 g/mL
• Gruppo funzionale: alkyne; carboxylic acid
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(CCOCCOCCOCCOCC#C)=O
• InChI: WMBXAUWIPBFEOK-UHFFFAOYSA-N

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Altre note

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Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Pittogrammi: GHS02
• Avvertenze: Danger
• Indicazioni di pericolo: H242
• Consigli di prudenza: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classi di pericolo: Self-react. C
• Codice della classe di stoccaggio: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable