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901500

Sigma-Aldrich

Pomalidomide-C3-CO2H

≥95%

Sinonimo/i:

4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader

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About This Item

Formula empirica (notazione di Hill):
C17H17N3O6
Numero CAS:
2225940-47-4
Peso molecolare:
359.33
Numero MDL:
MFCD32173777
Codice UNSPSC:
12352101
NACRES:
NA.22

ligand

pomalidomide

Livello qualitativo

100

Saggio

≥95%

Stato

powder or crystals

Impiego in reazioni chimiche

reactivity: amine reactive
reagent type: ligand-linker conjugate

Gruppo funzionale

carboxylic acid

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCC(O)=O)=O)NC1=O

InChI

1S/C17H17N3O6/c21-12-7-6-11(15(24)19-12)20-16(25)9-3-1-4-10(14(9)17(20)26)18-8-2-5-13(22)23/h1,3-4,11,18H,2,5-8H2,(H,22,23)(H,19,21,24)
DXQHHPDVZILLOC-UHFFFAOYSA-N

Categorie correlate

Applicazioni

Protein degrader builiding block Pomalidomide-C3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Altre note

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Codice della classe di stoccaggio

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Classe di pericolosità dell'acqua (WGK)

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Punto d’infiammabilità (°F)

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Punto d’infiammabilità (°C)

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Lot/Batch Number

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Articoli

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Global Trade Item Number

SKUGTIN
901500-50MG4061834671589

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