323322

Trimethylphosphine

97%

• Sinonimo/i: PMe₃
• Formula condensata: (CH₃)₃P
• Numero CAS: 594-09-2
• Peso molecolare: 76.08
• Beilstein: 969138
• Numero CE: 209-823-1
• Numero MDL: MFCD00008510
• Codice UNSPSC: 12352128
• ID PubChem: 24859357
• NACRES: NA.22

Proprietà

• Tensione di vapore: 7.24 psi ( 20 °C)
• Saggio: 97%
• Forma fisica: liquid
• Impiego in reazioni chimiche: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling; reagent type: ligand; reaction type: Mitsunobu Reaction; reagent type: ligand; reaction type: Wittig Reaction
• Indice di rifrazione: n20/D 1.428 (lit.)
• P. eboll.: 38-40 °C (lit.)
• Punto di fusione: −86 °C (lit.)
• Densità: 0.738 g/mL at 20 °C (lit.)
• Gruppo funzionale: phosphine
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CP(C)C
• InChI: 1S/C3H9P/c1-4(2)3/h1-3H3; YWWDBCBWQNCYNR-UHFFFAOYSA-N

Descrizione

Applicazioni

Trimethylphosphine (PMe₃) is an electron-rich phosphine ligand used as a reagent in Mitsunobu reaction.
It can be used:

• In transformation of azides into carbamates; aziridines to azidoalcohols; and ketoximes to ketones with 2,2′-dipyridyl diselenide.
• In Aza-Wittig reaction;, C-H bond activation of imines; cross-coupling reactions.
• In the preparation of (cyanomethylene) trimethylphosphorane (CMMP) which is used as a reagent in Mitsunobu type reaction.
• As a reagent in the synthesis of ruthenium trimethylphosphine complexes, which in turn are used as catalysts for hydrogenation of CO₂ to formic acid.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H315,H319,H335
• Consigli di prudenza: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): -2.2 °F - closed cup
• Punto d’infiammabilità (°C): -19 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves