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1607007

USP

Sacarina

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

2,3-Di-hidroxi-1,2-benzisotiazol-3-ona-1,1-dióxido, Sulfimida o-benzoica, Imida do ácido 2-sulfobenzoico

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About This Item

Fórmula empírica (Notação de Hill):
C7H5NO3S
Número CAS:
81-07-2
Peso molecular:
183.18
Beilstein:
6888
Número MDL:
MFCD00005866
Código UNSPSC:
41116107
ID de substância PubChem:
329751066
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

saccharin

fabricante/nome comercial

USP

pf

226-229 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

chave InChI

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Saccharin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Saccharin Sodium Tablets

Ações bioquímicas/fisiológicas

Um sabor doce para mamíferos. Foi proposto um sítio de ligação do receptor de sabor de glicerol específico para glicose em drosófila.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

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Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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The toxicological effects of saccharin in short-term genotoxicity assays.
D L Arnold et al.
Mutation research, 221(2), 69-132 (1989-09-01)
M D Reuber
Environmental health perspectives, 25, 173-200 (1978-08-01)
Saccharin is carcinogenic for the urinary bladder in rats and mice, and most likely is carcinogenic in human beings. The neoplasms of the urinary bladder are malignant and invade and metastasize. Male rats are more susceptible to urinary bladder carcinogenesis
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 225-252 (1996-01-01)
Sodium saccharin (NaSac) produces bladder tumors consistently in male rats only after lifetime exposure that begins at birth. NaSac is not metabolized and is negative in most genotoxicity tests. NaSac-induced cell damage and proliferation have been proposed as important factors
Marilyn E Carroll et al.
Behavioural pharmacology, 19(5-6), 435-460 (2008-08-12)
A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence
L B Ellwein et al.
Critical reviews in toxicology, 20(5), 311-326 (1990-01-01)
Almost from its discovery in 1879, the use of saccharin as an artificial, non-nutritive sweetener has been the center of several controversies regarding potential toxic effects, most recently focusing on the urinary bladder carcinogenicity of sodium saccharin in rats when
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