1332000

Hydroxyurea

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): Hydroxycarbamide
• Fórmula linear: NH₂CONHOH
• Número CAS: 127-07-1
• Peso molecular: 76.05
• Beilstein: 1741548
• Número MDL: MFCD00007943
• Código UNSPSC: 41116107
• ID de substância PubChem: 329750138
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: hydroxyurea
• fabricante/nome comercial: USP
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• chave InChI: VSNHCAURESNICA-UHFFFAOYSA-N
• Informações sobre genes: human ... RRM1(6240) , RRM2(6241) , RRM2B(50484)

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Ações bioquímicas/fisiológicas

Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H340,H361
• Declarações de precaução: P201 - P280 - P308 + P313
• Classificações de perigo: Muta. 1B - Repr. 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable