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Q0632

Sigma-Aldrich

Quinapril hydrochloride

≥98% (HPLC), solid

Sinônimo(s):

(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C25H30N2O5 · HCl
Número CAS:
82586-55-8
Peso molecular:
474.98
Número MDL:
MFCD00889215
Código UNSPSC:
41116107
ID de substância PubChem:
329823858
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

cor

white

solubilidade

H2O: >10 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(O)=O

InChI

1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1

chave InChI

IBBLRJGOOANPTQ-JKVLGAQCSA-N

Informações sobre genes

human ... ACE(1636)

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Aplicação

Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.

Ações bioquímicas/fisiológicas

Quinapril has been studied to exhibit therapeutic effects against hypertension and congestive heart failure.
Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H361d,H372

Classificações de perigo

Repr. 2 - STOT RE 1

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Marek Rajzer et al.
Thrombosis research, 130(1), 99-103 (2011-09-16)
We sought to determine plasma fibrin clot properties in hypertensive subjects and to evaluate potential effects of antihypertensive therapy on these parameters. Sixty-one patients (30 men, 31 women) with essential arterial hypertension stage 1 or 2 (aged 46.6 ± 14.4
D Lyons et al.
European journal of clinical pharmacology, 51(5), 373-378 (1997-01-01)
Different ACE inhibitors can be distinguished in vitro by their affinity for converting enzyme in vascular and other tissues. Quinapril appears to be amongst the more effective inhibitors of vascular tissue ACE in vitro. This study assesses the in vivo
Marcel Ruzicka et al.
American journal of hypertension, 23(11), 1179-1182 (2010-07-17)
Angiotensin-converting enzyme (ACE) inhibitors differ in their lipophilic/hydrophilic index that determines their tissue bioavailability and affinity to ACE, which may result in major differences in the degree of blockade of cardiac ACE. We evaluated the hypothesis that in patients with
Tomoe Fujita et al.
The Journal of pharmacology and experimental therapeutics, 341(3), 626-633 (2012-03-06)
Indoxyl sulfate (IS) is an organic anion uremic toxin that accumulates in patients with chronic kidney disease (CKD). The aims of this study were to examine the kinetic profiles of IS in humans at a steady state after multiple doses
Shumet A Hailu et al.
Journal of pharmaceutical sciences, 99(6), 2786-2799 (2010-01-22)
To determine the surface acidity and stability profiles of quinapril hydrochloride (QHCl) coground with silicates, solid-state equivalent pH (pHeq) of amorphous samples was measured by diffuse reflectance spectroscopy using pH indicator probes. Calibration curves for pH indicators were developed in
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