PHL80431

Dihydromyricetin

phyproof^® Reference Substance

• Sinônimo(s): (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one, 3,3′,4′,5,5′,7-Hexahydroxyflavanone, Ampelopsin, Ampeloptin, DHM
• Fórmula empírica (Notação de Hill): C₁₅H₁₂O₈
• Número CAS: 27200-12-0
• Peso molecular: 320.25
• Número MDL: MFCD00189451
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: primary reference standard
• linha de produto: phyproof^® Reference Substance
• Ensaio: ≥95.0% (HPLC)
• forma: solid
• fabricante/nome comercial: PhytoLab
• cadeia de caracteres SMILES: O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(O)=C(C(O)=C3)O)[C@H]1O
• InChI: 1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
• chave InChI: KJXSIXMJHKAJOD-LSDHHAIUSA-N

Descrição

Descrição geral

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Aplicação

• Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease. This review discusses the role of Hovenia dulcis, from which dihydromyricetin is derived, in treating alcohol-associated liver conditions, highlighting its mechanisms and therapeutic potentials (He YX, Liu MN, Wang YY, et al. 2024).


• Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway. This study explores how dihydromyricetin influences liver health, particularly in hepatic steatosis and insulin resistance, offering insights into its mechanisms through autophagy pathways (Yang Y, Qiu W, Xiao J, et al. 2024).


• Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin. Research identifies dihydromyricetin′s potential anti-aging effects on human skin by modulating DNA methylation, which could contribute to its broader use in dermatological products (Falckenhayn C, Bienkowska A, Söhle J, et al. 2023).


• Dihydromyricetin reverses capecitabine-induced peripheral myelin dysfunction through modulation of oxidative stress. This article provides evidence of dihydromyricetin′s protective effects against peripheral myelin damage due to oxidative stress, relevant in the treatment of certain neuropathies (Fang J, Lou S, Zhou X, et al. 2024).


• The Molecular Mechanism Underlying the Therapeutic Effect of Dihydromyricetin on Type 2 Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Transcriptomics. This comprehensive study details the molecular interactions and pathways through which dihydromyricetin could affect type 2 diabetes, providing a foundation for its application in metabolic disorder treatments (Wen X, Lv C, Zhou R, et al. 2024).

Ações bioquímicas/fisiológicas

Dihydromyricetin (Ampelopsin) is a flavanonol with antioxidant and anti-cancer activity, found to have anti-alcohol intoxication effects. Its anti-alcohol effects appear to be by its actions as a positive modulator of GABA-A receptors at the benzodiazepine site.

Informações legais

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable