T2455

T3MG

• Sinônimo(s): (±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
• Fórmula empírica (Notação de Hill): C₆H₁₁NO₄
• Número CAS: 63088-04-0
• Peso molecular: 161.16
• Número MDL: MFCD09836097
• Código UNSPSC: 12352200
• ID de substância PubChem: 329826708
• NACRES: NA.77

Propriedades

• forma: powder
• Nível de qualidade: 100
• cor: white to off-white
• solubilidade: H₂O: >1.5 mg/dL
• adequação: suitable for TLC (single spot)
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
• chave InChI: FHJNAFIJPFGZRI-WVZVXSGGSA-N

Descrição

Ações bioquímicas/fisiológicas

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

Características e benefícios

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315 - H319 - H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable