T2252
apo-Transferrina
≥95% protein basis (biuret)
Sinônimo(s):
Siderofilina, Transferrina humana
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About This Item
Produtos recomendados
fonte biológica
human
Nível de qualidade
Ensaio
≥95% protein basis (biuret)
≥98% (agarose gel electrophoresis)
forma
powder
peso molecular
76-81 kDa
técnica(s)
cell culture | mammalian: suitable
solubilidade
H2O: 50 mg/mL
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... TF(7018)
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Descrição geral
Transferrin is a bilobed glycoprotein containing an N-terminal lobe and a C-terminal lobe. Each of these domains is divided into two sub-domains and within the inter subdomain cleft is the metal-binding site. A single transferrin molecule can bind to two ferric ions. Apo-transferrin is an iron-free form.
Aplicação
Apo-transferrin has been shown to strongly inhibit bacterial adhesion to biomaterials including polystyrene, polymethylmethacrylate, and silicone. Inhibition was seen at twenty micrograms/ml in culture medium.
apo-Transferrin human has been used in Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 to culture:
- pancreatic ductal adenocarcinoma (PDAC) cell lines
- oligodendrocytes
- renal proximal tubule epithelial cells (RPTEC/TERT1) cells
Ações bioquímicas/fisiológicas
Transferrin transports iron through receptor-mediated endocytosis. The iron transport mechanism occurs in the endothelial cells of the blood-brain barrier. Transferrin maintains iron homeostasis and is an iron-associated marker. Reduced levels of transferrin are observed in severe COVID-19 conditions. It may bind to other molecules apart from iron, hence it can be used in targeted drug delivery.
Outras notas
Proteína transportadora de ferro não heme.
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
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International journal of molecular sciences, 22(24) (2021-12-25)
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Jacob M Smigiel et al.
Molecular cancer research : MCR, 15(4), 478-488 (2017-01-06)
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 116, 74-79 (2021-12-25)
Mounting evidence links hyperinflammation in gravely ill patients to low serum iron levels and hyperferritinemia. However, little attention has been paid to other iron-associated markers such as transferrin. The aim of this study was to investigate the association of different
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Artificial organs, 26(6), 512-520 (2002-06-20)
Apo-transferrin (apo-Tf), the iron deficient form of Tf, has been identified previously as a potent inhibitor of Staphylococcus epidermidis adhesion to polyurethane surfaces. In this study, the ability of apo-Tf to suppress the adhesion of two other strains of bacteria
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