SRP6159
FGF-basic human
recombinant, expressed in human cells, ≥95% (SDS-PAGE)
Sinônimo(s):
FGF-2, FGF-b, HBGF-2, HBGH-2, Prostatropin
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About This Item
Produtos recomendados
fonte biológica
human
recombinante
expressed in human cells
Ensaio
≥95% (SDS-PAGE)
Formulário
lyophilized
peso molecular
17 kDa (monomer, non-glycosylated)
embalagem
pkg of 10 μg
técnica(s)
cell culture | mammalian: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... FGF2(2247)
Descrição geral
FGF-basic is a member of the fibroblast growth factor (FGF) family. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. The gene encoding this protein is localized on human chromosome 4q28.
Ações bioquímicas/fisiológicas
FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The protein associates with fibroblast growth factor receptors 1, 2 and 3 (FGFR-1, -2, -3).
forma física
Lyophilized from a PBS solution.
Nota de preparo
Centrifuge the vial prior to opening.
Reconstituição
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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We have shown previously that fibrin(ogen) binding potentiates the capacity of fibroblast growth factor 2 (FGF-2) to stimulate endothelial cell (EC) proliferation. We have now investigated the receptor requirement for EC proliferation by fibrinogen-bound FGF-2. ECs were cultured with 25
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