SRP5161
4EBP1, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
BP-1, EIF4EBP1, MGC4316, PHAS-I
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About This Item
Produtos recomendados
fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥70% (SDS-PAGE)
forma
buffered aqueous glycerol solution
peso molecular
~40 kDa
nº de adesão NCBI
aplicação(ões)
cell analysis
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... EIF4EBP1(1978)
Descrição geral
Eukaryotic translation initiation factor 4E binding protein 1 (E1F4EBP1) is part of the translation repressor protein family. The gene encoding it is localized on human chromosome 8p11-p12.
Ações bioquímicas/fisiológicas
Eukaryotic translation initiation factor 4E binding protein 1 (E1F4EBP1) is involved in protein synthesis, cell growth and survival. In the unphosphorylated form, it suppresses the translation initiation of capped mRNAs, whereas in phosphorylated form, it increases translation initiation. Phosphorylation of E1F4EBP1 releases it from eukaryotic translation initiation factor 4E (eIF4E) and this results in cap-dependent translation. The protein is also involved in tumorigenesis and the gene is overexpressed in various carcinomas. It is also a substrate for mTORC1 (mammalian target of rapamycin complex 1). In non-phosphorylated conditions, E1F4EBP1 interacts with p21 (cyclin-dependent kinase inhibitor) and enhances destabilization of p21.
forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparo
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.
Yang ZQ
Cancer Research (2006)
4E-BP1, a multifactor regulated multifunctional protein.
Qin X
Cell Cycle (2016)
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.
Llanos S
Nature Communications (2016)
K Tsukiyama-Kohara et al.
Genomics, 38(3), 353-363 (1996-12-15)
Two related eukaryotic initiation factor-4E binding proteins (4E-BP1 and 4E-BP2) were recently characterized for their capacity to bind specifically to eIF4E and inhibit its function. Here, we determined the cDNA sequence, tissue distribution, genomic structure, and chromosome localization of murine
A Pause et al.
Nature, 371(6500), 762-767 (1994-10-27)
The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of
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