SRP4702
CTGF human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinônimo(s):
connective tissue growth factor
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About This Item
Produtos recomendados
fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥95% (HPLC)
≥95% (SDS-PAGE)
forma
lyophilized
potência
501.0-2.0 μg/mL ED50
peso molecular
~11.2 kDa
embalagem
pkg of 20 μg
Impurezas
endotoxin, tested
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... CTGF(1490)
Categorias relacionadas
Descrição geral
The gene CTGF (connective tissue growth factor) is mapped to human chromosome 6q23.2. CTGF is a member of the CCN (Cyr61, CTGF , Nov) family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. The protein has an N-terminal secretory signal peptide and four domains (an insulin-like growth factor-binding protein domain, a Von Willebrand factor domain, a thrombospondin type-1 repeat module, and a CT). It is expressed in various tissues, such as connective tissue, heart, brain, kidney, lung, liver, muscle, pancreas gland and placenta. Recombinant human CTGF is a 11.2Da protein of 98 amino acid residues.
Ações bioquímicas/fisiológicas
CTGF (connective tissue growth factor) stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells. It binds to IGF (insulin growth factor), TGF (transforming growth factor) β1 and BMP (bone morphogenetic protein)-4. CTGF plays a crucial role in the progression of diabetic nephropathy. It can work as an oncoprotein in glioma and melanoma. However, it works as a tumor suppressor in lung cancer and colon cancer.
forma física
Sterile filtered and Lyophilized without additives.
Reconstituição
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
Wang S, et al.
Journal of Diabetes Research, 2015, 962383-962383 (2015)
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
Zhu X, et al.
Oncotarget, 6, 25320-25338 (2015)
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Kikuchi R, et al.
Cancer Research, 67, 7095-7105 (2007)
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
Li J, et al.
International Journal of Molecular Medicine, 36, 1451-1463 (2015)
Hsiao-Chi Tsai et al.
Oncotarget, 5(11), 3800-3812 (2014-07-09)
Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a secreted protein, binds to integrins, modulates invasive behavior of certain human cancer cells. Effect of CTGF in
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