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Documentos

SML3136

Sigma-Aldrich

CGP-54626

≥95% (HPLC)

Sinônimo(s):

CGP-54626A, Cyclohexylmethyl((S)-3-((S)-1-(3,4-dichlorophenyl)ethylamino)-2-hydroxypropyl)phosphinic acid hydrochloride, P-(Cyclohexylmethyl)-P -[(2S )-3-[[(1S )-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-phosphinic acid hydrochloride, [3-[N-[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-(2S)-hydroxypropyl](cyclohexylmethyl)phosphinic acid hydrochloride, [S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C18H28Cl2NO3P · HCl
Número CAS:
149184-21-4
Peso molecular:
444.76
Número MDL:
MFCD09878291
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥95% (HPLC)

forma

powder

cor

white to beige

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

ClC1=C(C=CC([C@@H](NC[C@@H](CP(CC2CCCCC2)(O)=O)O)C)=C1)Cl.Cl

InChI

1S/C18H28Cl2NO3P.ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14;/h7-9,13-14,16,21-22H,2-6,10-12H2,1H3,(H,23,24);1H/t13-,16-;/m0./s1

chave InChI

ZQCFHOVIXCJPLE-LINSIKMZSA-N

Ações bioquímicas/fisiológicas

CGP-54626 is an orally available, potent selective GABAB receptor antagonist with an IC50 of 4 nM that binds to orthosteric site of (Kd = 33.1 nM) GABA(B)-R1. CGP 54626 decreases a sensitivity to ethanol in Drosophila melanogaster model.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Daniel C Ranson et al.
Addiction biology, 25(2), e12725-e12725 (2019-02-15)
When exposed to ethanol, Drosophila melanogaster display a variety of addiction-like behaviours similar to those observed in mammals. Sensitivity to ethanol can be quantified by measuring the time at which 50% of the flies are sedated by ethanol exposure (ST50);
A Rory McQuiston
The Journal of physiology, 588(Pt 19), 3727-3742 (2010-08-10)
During theta rhythm, the timing of inputs to hippocampal CA1 from the perforant path (PP) of the entorhinal cortex and the Schaffer collaterals (SCs) from individual CA3 pyramidal neurons can vary within an individual theta period. Importantly, during theta rhythms
Yeechan Wu et al.
Journal of neurophysiology, 105(6), 2715-2728 (2011-03-25)
Noradrenergic (NAergic) A7 neurons that project axonal terminals to the dorsal horn of the spinal cord to modulate nociceptive signaling are suggested to receive tonic inhibition from local GABAergic interneurons, which are under the regulation of descending analgesic pathways. In

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