SML1506

KY-05009

≥98% (HPLC)

• Sinônimo(s): 5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide, 5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide
• Fórmula empírica (Notação de Hill): C₁₈H₁₆N₄O₂S
• Número CAS: 1228280-29-2
• Peso molecular: 352.41
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825926
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: light yellow to dark yellow
• solubilidade: DMSO: 10 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O
• InChI: 1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)
• chave InChI: WCEDGRTWDSHZHF-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.

KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable