SML1466

ABH hydrochloride

≥98% (HPLC)

• Sinônimo(s): 2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride
• Fórmula empírica (Notação de Hill): C₆H₁₄BNO₄ · HCl
• Número CAS: 194656-75-2
• Peso molecular: 211.45
• Número MDL: MFCD22887376
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825900
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D +8 to +13°, c = 0.7 in H₂O
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: 20 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
• InChI: 1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
• chave InChI: XCUVEZUCSHVMRK-JEDNCBNOSA-N

Descrição

Ações bioquímicas/fisiológicas

ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.

Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable